This proposal requests funds for leave time and modest resources to expand a knowledge base in mathematical biology in order to contribute an analytical perspective toward a broad spectrum of global health issues. The investigator is trained in numerical analysis of partial differential equations with applications in continuum mechanics and will be on sabbatical leave from Wabash College for the 2011-2012 academic year. Research in the dynamics of infectious diseases involves development and analysis of systems of ordinary differential equations, an interdisciplinary area of study involving mathematics, computation, and biology. While the mathematics of the proposed area of study is clearly in itself a new direction, it is the biological and epidemiological background that comprises the most new territory for the project. Support will provide an opportunity to interact with researchers in mathematical biology at the University of Colorado, leveraging opportunities not available at Wabash College. Topics of exploration include: biological background and literature review in epidemiological modeling and calibrating model parameters using biological data. This project aims to contribute toward another GLCA supported project in global health.