In this proposal, I request funding to support a significant change in my research focus into the field of cancer biology. Specifically, I propose to conduct experiments on the effects of exercise on colon tumor incidence and progression using the mouse as a model organism. I request funding for the following: i) travel costs for training in mouse endoscopy methods; ii) travel and registration costs for a week-long, intensive short-course on computational and experimental approaches to genetic studies in the mouse; and iii) instrumentation needed to monitor colon tumor progression. This project will be collaboration with Dr. Scott Kelly, a colleague in the Department of Zoology here at Ohio Wesleyan University (OWU). Dr. Kelly has extensive research and husbandry experience with mice and has already established a mouse housing facility and breeding colony here at OWU. Until now, I have used the single-celled fission yeast S. pombe as a model for my research on the molecular mechanisms that underlie differential gene expression. The mouse cancer project is a unique opportunity for me to draw on my experience in molecular biology and comparative genomics in a distinctly different and exciting research area.