Patients with Parkinson's disease (PD) may resort to deep brain stimulation (DBS), a treatment in which electrodes are implanted into the subthalamic nucleus (STN) of the brain, providing relief from tremors and other signs of the disease. This treatment has proven effective for many PD patients, however, the main side effects are due to cell death around the electrode that leads to an ineffectiveness of DBS to ameliorate the signs of Parkinson's disease. Resveratrol (RESV) is a plant derivative that is known to have protective effects in cells. We hypothesized that RESV may have neuroprotective effects and can prevent brain lesions associated with the physical presence of electrodes in the brain. Our initial studies suggest that treatment with RESV prevents signs of brain damage and the motor deficits associated with brain damage, similar to that observed in PD patients. Our studies suggest that RESV may have neuroprotective effects and may be a useful tool in the treatment of Parkinson's disease.